Alessandro Plebani Selected Research

Agammaglobulinemia (Hypogammaglobulinemia)

1/2019	A novel monoallelic gain of function mutation in p110δ causing atypical activated phosphoinositide 3-kinase δ syndrome (APDS-1).
1/2019	Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort.
1/2016	Cohort of Iranian Patients with Congenital Agammaglobulinemia: Mutation Analysis and Novel Gene Defects.
2/2009	Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.
12/2008	Ig beta deficiency in humans.
9/2008	Autosomal recessive agammaglobulinemia: novel insights from mutations in Ig-beta.
9/2007	Mutations of the Igbeta gene cause agammaglobulinemia in man.
7/2006	Linkage of autosomal-dominant common variable immunodeficiency to chromosome 4q.
2/2005	The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency.
4/2004	Search for poliovirus long-term excretors among patients affected by agammaglobulinemia.

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Alessandro Plebani Research Topics

Disease

14	Infections 09/2021 - 09/2002
14	Common Variable Immunodeficiency 09/2021 - 03/2003
10	Agammaglobulinemia (Hypogammaglobulinemia) 01/2019 - 04/2004
5	Lung Diseases (Lung Disease) 01/2020 - 05/2007
5	Job Syndrome (Hyper-IgE Syndrome) 07/2019 - 01/2008
4	Ataxia Telangiectasia (Louis Bar Syndrome) 11/2021 - 09/2012
4	Type 1 Hyper-IgM Immunodeficiency Syndrome 01/2021 - 07/2003
4	Primary Immunodeficiency Diseases 01/2019 - 12/2002
4	Chronic Granulomatous Disease 06/2014 - 11/2004
4	Bruton type agammaglobulinemia 06/2011 - 03/2002
4	Pneumonia (Pneumonitis) 06/2011 - 02/2005
4	Hyper-IgM Immunodeficiency Syndrome (Hyper-IgM Syndrome) 02/2005 - 12/2002
3	Bronchiectasis 01/2021 - 02/2005
3	Reinfection 01/2020 - 07/2006
3	Poliomyelitis (Polio) 01/2019 - 05/2003
3	Ataxia (Dyssynergia) 06/2015 - 09/2012
2	Exanthema (Rash) 07/2019 - 02/2010
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2019 - 02/2005
2	Lymphopenia (Lymphocytopenia) 01/2019 - 03/2016
2	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 11/2014
2	Herpes Simplex 01/2016 - 12/2010
2	Neoplasms (Cancer) 08/2014 - 02/2009
2	Inflammation (Inflammations) 10/2011 - 08/2009
2	Hyperplasia 06/2011 - 01/2004
2	HIV Infections (HIV Infection) 07/2010 - 09/2008
2	IgA Deficiency 12/2009 - 03/2003
2	Hepatitis B 01/2005 - 03/2002
1	Kidney Diseases (Kidney Disease) 05/2022
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2022
1	Portal Hypertension 09/2021
1	Hepatopulmonary Syndrome 09/2021
1	Staphylococcal Infections 09/2021
1	Cytopenia 01/2021
1	Splenomegaly 01/2021
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2019
1	Persistent Infection 01/2019
1	Hemorrhage 04/2018
1	Leukocyte adhesion deficiency type 1 01/2018
1	Chronic Mucocutaneous Candidiasis 08/2017
1	Hypersensitivity (Allergy) 11/2016
1	Immune System Diseases (Immune Disorders) 11/2014
1	Leukemia 08/2014
1	Multiple Sclerosis 08/2014
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 08/2014
1	Inborn Genetic Diseases (Disease, Hereditary) 05/2014
1	Congenital Heart Defects (Congenital Heart Defect) 01/2014
1	Language Development Disorders (Semantic-Pragmatic Disorder) 01/2014

Drug/Important Bio-Agent (IBA)

9	Immunoglobulins (Immunoglobulin)IBA 01/2020 - 07/2006
8	Immunoglobulin M (IgM)IBA 01/2019 - 04/2003
7	Immunoglobulin G (IgG)IBA 01/2021 - 09/2002
6	Immunoglobulin A (IgA)IBA 11/2021 - 02/2005
4	Immunoglobulin E (IgE)IBA 07/2019 - 02/2005
4	AntibodiesIBA 01/2019 - 01/2005
4	Cytidine DeaminaseIBA 01/2019 - 07/2003
4	NADPH Oxidases (NAD(P)H oxidase)IBA 02/2013 - 11/2004
4	Proteins (Proteins, Gene)FDA Link 07/2011 - 12/2002
3	AntigensIBA 09/2021 - 03/2002
3	VaccinesIBA 01/2019 - 04/2003
3	Agammaglobulinaemia Tyrosine KinaseIBA 01/2019 - 03/2002
3	CD40 Ligand (CD40L)IBA 01/2019 - 12/2002
3	Dexamethasone (Maxidex)FDA LinkGeneric 01/2018 - 01/2014
3	Pharmaceutical PreparationsIBA 03/2016 - 10/2011
3	IsoprostanesIBA 04/2013 - 02/2011
3	LigandsIBA 12/2010 - 12/2003
3	Intravenous Immunoglobulins (IVIG)FDA Link 05/2007 - 09/2002
2	Biomarkers (Surrogate Marker)IBA 05/2022 - 02/2013
2	STAT1 Transcription FactorIBA 08/2017 - 08/2011
2	NF-kappa B (NF-kB)IBA 01/2017 - 11/2014
2	InterferonsIBA 01/2016 - 12/2010
2	Pre-B Cell ReceptorsIBA 01/2016 - 12/2008
2	B-Cell Activation Factor ReceptorIBA 04/2014 - 09/2005
2	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 04/2013 - 02/2011
2	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2012 - 01/2008
2	Glutens (Glutelin)IBA 08/2012 - 03/2010
2	Toll-Like Receptor 9IBA 01/2012 - 12/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008 - 03/2006
2	Polysaccharides (Glycans)IBA 02/2005 - 04/2003
1	Ganciclovir (Cytovene)FDA LinkGeneric 09/2021
1	Valganciclovir FDA Link 09/2021
1	letermovirIBA 09/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2020
1	MacrolidesIBA 01/2019
1	LipopolysaccharidesIBA 01/2019
1	Azithromycin (Zithromax)FDA LinkGeneric 01/2019
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2019
1	recombinant FVIIa (rFVIIa)FDA Link 04/2018
1	IntegrinsIBA 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 08/2017
1	Deoxyribonucleases (DNase)FDA Link 11/2016
1	Granzymes (Granzyme)IBA 01/2016
1	SteroidsIBA 06/2015
1	A-factor (Streptomyces)IBA 08/2014
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 08/2014
1	GTP-Binding Proteins (G-Protein)IBA 08/2014
1	Sphingosine-1-Phosphate ReceptorsIBA 08/2014
1	NADPH Oxidase 2IBA 06/2014
1	CalciumIBA 01/2014
1	Phosphorus (Red Phosphorus)IBA 01/2014

Therapy/Procedure

9	Therapeutics 01/2021 - 01/2004
1	Liver Transplantation 09/2021